ACER2

Ceramidase enzyme
ACER2
Identifiers
AliasesACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2
External IDsOMIM: 613492; MGI: 1920932; HomoloGene: 14986; GeneCards: ACER2; OMA:ACER2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ACER2
Genomic location for ACER2
Band9p22.1Start19,409,009 bp[1]
End19,452,505 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ACER2
Genomic location for ACER2
Band4|4 C4Start86,792,633 bp[2]
End86,853,059 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • urinary bladder

  • placenta

  • subcutaneous adipose tissue

  • stomach

  • body of stomach

  • duodenum

  • body of pancreas

  • islet of Langerhans

  • stromal cell of endometrium

  • rectum
Top expressed in
  • right lung

  • right lung lobe

  • left lung

  • atrium

  • left lung lobe

  • morula

  • aortic valve

  • blood

  • brown adipose tissue

  • ascending aorta
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • dihydroceramidase activity
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  • hydrolase activity
  • N-acylsphingosine amidohydrolase activity
  • ceramidase activity
  • metal ion binding
Cellular component
  • integral component of membrane
  • integral component of Golgi membrane
  • Golgi apparatus
  • membrane
  • Golgi membrane
Biological process
  • positive regulation of cell death
  • response to retinoic acid
  • ceramide metabolic process
  • lipid metabolism
  • sphingosine biosynthetic process
  • sphingolipid biosynthetic process
  • negative regulation of cell-matrix adhesion
  • positive regulation of cell population proliferation
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • negative regulation of cell adhesion mediated by integrin
  • cellular response to DNA damage stimulus
  • regulation of autophagy
  • DNA damage response, signal transduction by p53 class mediator
  • regulation of apoptotic process
  • ceramide catabolic process
  • sphingolipid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

340485

230379

Ensembl

ENSG00000177076

ENSMUSG00000038007

UniProt

Q5QJU3

Q8VD53

RefSeq (mRNA)

NM_001010887

NM_001290541
NM_001290543
NM_139306
NM_028605

RefSeq (protein)

NP_001010887

NP_001277470
NP_001277472
NP_647467

Location (UCSC)Chr 9: 19.41 – 19.45 MbChr 4: 86.79 – 86.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.[5]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177076 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038007 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.
  6. ^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876.

External links

Further reading

  • Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. S2CID 20973940.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.


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