Asialoglycoprotein
Class of glycoproteins from which sialic acid has been removed by the action of sialidases
If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.[1][2]
In rats, the exposure of subterminal galactose or GalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptors on Kuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.[3]
External links
- Asialoglycoproteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Gross, Hans Jürgen; Brossmer, Reinhard (1987-06-01). "N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein". Glycoconjugate Journal. 4 (2): 145–156. doi:10.1007/BF01049452. ISSN 1573-4986. S2CID 7911178.
- ^ Regoeczi, E.; Chindemi, P. A. (1981-01-01). "The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance". Growth. 45 (1): 19–28. ISSN 0017-4793. PMID 7227848.
- ^ Fadden AJ, Holt OJ, Drickamer K (2003). "Molecular characterization of the rat Kupffer cell glycoprotein receptor". Glycobiology. 13 (7): 529–537. doi:10.1093/glycob/cwg068. PMID 12672702.
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