CEACAM7

Protein-coding gene in the species Homo sapiens

CEACAM7

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
4Y89

Identifiers

Aliases

CEACAM7, CEA, CGM2, carcinoembryonic antigen related cell adhesion molecule 7, CEA cell adhesion molecule 7

External IDs

HomoloGene: 48476; GeneCards: CEACAM7; OMA:CEACAM7 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.2	Start	41,673,303 bp^[1]
Band	19q13.2	End	41,706,976 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

rectum

appendix

islet of Langerhans

gallbladder

palpebral conjunctiva

vagina

cervix epithelium

pancreatic ductal cell

epithelium of esophagus

oral cavity

n/a

More reference expression data

BioGPS


More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1087


n/a

Ensembl


ENSG00000280501 ENSG00000007306


n/a

UniProt


Q14002


n/a

RefSeq (mRNA)


NM_006890 NM_001291485


n/a

RefSeq (protein)


NP_001278414 NP_008821


n/a

Location (UCSC)

Chr 19: 41.67 – 41.71 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c ENSG00000007306 GRCh38: Ensembl release 89: ENSG00000280501, ENSG00000007306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thompson J, Zimmermann W, Nollau P, Neumaier M, Weber-Arden J, Schrewe H, Craig I, Willcocks T (Jan 1995). "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas". J Biol Chem. 269 (52): 32924–31. doi:10.1016/S0021-9258(20)30079-X. PMID 7806520.
^ Thompson J, Seitz M, Chastre E, Ditter M, Aldrian C, Gespach C, Zimmermann W (May 1997). "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis". Cancer Res. 57 (9): 1776–84. PMID 9135022.
^ "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7".

External links

Human CEACAM7 genome location and CEACAM7 gene details page in the UCSC Genome Browser.

Douard R, Wind P, Sales JP, et al. (2006). "Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay". Surgery. 139 (4): 556–62. doi:10.1016/j.surg.2005.09.025. PMID 16627067.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schölzel S, Zimmermann W, Schwarzkopf G, et al. (2000). "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas". Am. J. Pathol. 156 (2): 595–605. doi:10.1016/S0002-9440(10)64764-5. PMC 1850034. PMID 10666389.
Frängsmyr L, Baranov V, Hammarström S (1999). "Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat". Tumour Biol. 20 (5): 277–92. doi:10.1159/000030075. PMID 10436421. S2CID 46856322.
Kinugasa T, Kuroki M, Takeo H, et al. (1998). "Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas". Int. J. Cancer. 76 (1): 148–53. doi:10.1002/(SICI)1097-0215(19980330)76:1<148::AID-IJC23>3.0.CO;2-7. PMID 9533775.
Thompson JA, Mauch EM, Chen FS, et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. CiteSeerX 10.1.1.657.2780. doi:10.1016/0006-291X(89)92821-0. PMID 2537643.
Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics. 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.