Dexbrompheniramine

Chemical compound
  • R06AB06 (WHO)
Legal statusLegal status
  • CA: OTC
  • US: OTC
Pharmacokinetic dataElimination half-life25 hoursIdentifiers
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
CAS Number
  • 132-21-8 checkY
PubChem CID
  • 16960
IUPHAR/BPS
  • 7588
DrugBank
  • DB00405 checkY
ChemSpider
  • 16068 checkY
UNII
  • 75T64B71RP
ChEBI
  • CHEBI:59269 checkY
ChEMBL
  • ChEMBL1201287 ☒N
CompTox Dashboard (EPA)
  • DTXSID8022905 Edit this at Wikidata
ECHA InfoCard100.004.595 Edit this at WikidataChemical and physical dataFormulaC16H19BrN2Molar mass319.246 g·mol−13D model (JSmol)
  • Interactive image
  • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
InChI
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
  • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

Interactions

MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Drinking alcohol can increase side effects of dexbrompheniramine.

References

  1. ^ Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of International Medical Research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306. S2CID 39205584.

External links

  • Media related to Dexbrompheniramine at Wikimedia Commons
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mAChRsTooltip Muscarinic acetylcholine receptors
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Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
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nAChRsTooltip Nicotinic acetylcholine receptors
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Muscarinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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H1
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H3
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Receptor/signaling modulators
Monoamine metabolism modulators
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