GCS1

Protein-coding gene in the species Homo sapiens

MOGS

Identifiers

Aliases

MOGS, CDG2B, CWH41, DER7, GCS1, mannosyl-oligosaccharide glucosidase

External IDs

OMIM: 601336; MGI: 1929872; HomoloGene: 4593; GeneCards: MOGS; OMA:MOGS - orthologs

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[1]

Band	6\|6 C3	Start	83,092,477 bp^[1]
Band	6\|6 C3	End	83,095,879 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of pancreas

body of stomach

stromal cell of endometrium

right uterine tube

right lobe of thyroid gland

minor salivary glands

right lobe of liver

left lobe of thyroid gland

anterior pituitary

upper lobe of left lung

Top expressed in

primitive streak

Paneth cell

condyle

cumulus cell

somite

fossa

fetal liver hematopoietic progenitor cell

lacrimal gland

epiblast

abdominal wall

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	glucosidase activity catalytic activity hydrolase activity hydrolase activity, acting on glycosyl bonds Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
Cellular component	integral component of membrane extracellular exosome membrane endoplasmic reticulum endoplasmic reticulum membrane
Biological process	metabolism protein N-linked glycosylation protein folding oligosaccharide metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7841


57377

Ensembl


n/a


ENSMUSG00000030036

UniProt


Q13724


Q80UM7

RefSeq (mRNA)


NM_006302 NM_001146158


NM_020619

RefSeq (protein)


NP_001139630 NP_006293


NP_065644

Location (UCSC)

n/a

Chr 6: 83.09 – 83.1 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.^[4]^[5]^[6]

Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.^[6]

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .^[7] .

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030036 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalz-Fuller B, Bieberich E, Bause E (Sep 1995). "Sexualization and expression of glucosidase I from human hippocampus". Eur J Biochem. 231 (2): 344–51. doi:10.1111/j.1432-1033.1995.tb20706.x. PMID 7635146.
^ Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G (Sep 1996). "Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 34 (3): 442–3. doi:10.1006/geno.1996.0313. PMID 8786151.
^ ^a ^b "Entrez Gene: GCS1 glucosidase I".
^ Goodman CD, McFadden GI (2008). "Gamete Fusion: Key Protein Identified". Current Biology. 18 (13): R571–R573. Bibcode:2008CBio...18.R571G. doi:10.1016/j.cub.2008.05.007. PMID 18606131. S2CID 14367758.

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Fenouillet E, Gluckman JC (1991). "Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein". J. Gen. Virol. 72 (8): 1919–26. doi:10.1099/0022-1317-72-8-1919. PMID 1678778.
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