MAGEA10

Protein-coding gene in humans

MAGEA10

Identifiers

Aliases

MAGEA10, CT1.10, MAGE10, MAGE family member A10

External IDs

OMIM: 300343; MGI: 3588211; HomoloGene: 121621; GeneCards: MAGEA10; OMA:MAGEA10 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq28	Start	152,133,310 bp^[1]
Band	Xq28	End	152,138,578 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A7.3	Start	71,425,476 bp^[2]
Band	X\|X A7.3	End	71,430,464 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

placenta

gonad

right testis

left testis

renal cortex

urinary bladder

vagina

ectocervix

gallbladder

Top expressed in

primary oocyte

zygote

secondary oocyte

blastocyst

spermatid

spermatocyte

testicle

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


4109


236852

Ensembl


ENSG00000124260


ENSMUSG00000043453

UniProt


P43363


A2AMW4

RefSeq (mRNA)


NM_021048 NM_001011543 NM_001251828


NM_001085506

RefSeq (protein)


NP_001011543 NP_001238757 NP_066386


NP_001078975

Location (UCSC)

Chr X: 152.13 – 152.14 Mb

Chr X: 71.43 – 71.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

MAGEA10 (MAGE family member A10) is a protein-coding gene in humans clustered at chromosomal location Xq28. ^[5]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124260 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043453 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MAGE family member A10". Retrieved 2017-06-15.

Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JM, Orringer MB, Beer DG (2004). "Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants". Clin. Cancer Res. 10 (17): 5708–16. doi:10.1158/1078-0432.CCR-04-0468. PMID 15355897.
Schultz-Thater E, Piscuoglio S, Iezzi G, Le Magnen C, Zajac P, Carafa V, Terracciano L, Tornillo L, Spagnoli GC (2011). "MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies". Int. J. Cancer. 129 (5): 1137–48. doi:10.1002/ijc.25777. PMID 21710496.
Badovinac Črnjević T, Tanja BČ, Spagnoli G, Giulio S, Juretić A, Antonio J, Jakić-Razumović J, Jasminka JR, Podolski P, Paula P, Šarić N, Nera Š (2012). "High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer". Med. Oncol. 29 (3): 1586–91. doi:10.1007/s12032-011-0120-9. PMID 22116775. S2CID 22748757.
Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W (2015). "MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles". Cell. Immunol. 297 (1): 10–8. doi:10.1016/j.cellimm.2015.05.004. PMID 26058806.