Myb proto-oncogene like 1

Protein-coding gene in the species Homo sapiens
MYBL1
Identifiers
AliasesMYBL1, A-MYB, AMYB, MYB proto-oncogene like 1
External IDsOMIM: 159405; MGI: 99925; HomoloGene: 32045; GeneCards: MYBL1; OMA:MYBL1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MYBL1
Genomic location for MYBL1
Band8q13.1Start66,562,175 bp[1]
End66,614,247 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for MYBL1
Genomic location for MYBL1
Band1 A2|1 2.08 cMStart9,737,640 bp[2]
End9,770,434 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • vena cava

  • sperm

  • body of tongue

  • Skeletal muscle tissue of rectus abdominis

  • pons

  • granulocyte

  • parotid gland

  • pericardium

  • superior surface of tongue
Top expressed in
  • spermatocyte

  • spermatid

  • zygote

  • secondary oocyte

  • tail of embryo

  • genital tubercle

  • female urethra

  • ventricular zone

  • primary oocyte

  • renal corpuscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • positive regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • mitotic cell cycle
  • male meiosis I
  • spermatogenesis
  • negative regulation of transposition
  • cell differentiation
  • piRNA biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4603

17864

Ensembl

ENSG00000185697

ENSMUSG00000025912

UniProt

P10243

P51960

RefSeq (mRNA)

NM_001080416
NM_001144755
NM_001294282

NM_001290397
NM_008651

RefSeq (protein)

NP_001073885
NP_001138227
NP_001281211

NP_001277326
NP_032677

Location (UCSC)Chr 8: 66.56 – 66.61 MbChr 1: 9.74 – 9.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185697 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025912 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MYB proto-oncogene like 1". Retrieved 2016-11-15.

Further reading

  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL (2013). "Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1". Proc. Natl. Acad. Sci. U.S.A. 110 (20): 8188–93. Bibcode:2013PNAS..110.8188R. doi:10.1073/pnas.1300252110. PMC 3657784. PMID 23633565.


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