Somatostatin receptor 5

Protein-coding gene in the species Homo sapiens
SSTR5
Identifiers
AliasesSSTR5, SS-5-R, Somatostatin receptor 5
External IDsMGI: 894282 HomoloGene: 20287 GeneCards: SSTR5
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for SSTR5
Genomic location for SSTR5
Band16p13.3Start1,072,747 bp[1]
End1,081,454 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SSTR5
Genomic location for SSTR5
Band17 A3.3|17 12.62 cMStart25,708,849 bp[2]
End25,716,262 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • left ventricle

  • ascending aorta

  • right coronary artery

  • metanephros

  • kidney

  • duodenum

  • mouth

  • minor salivary glands

  • left coronary artery
Top expressed in
  • soleus muscle

  • entorhinal cortex

  • superior frontal gyrus

  • primary motor cortex

  • superior colliculus

  • basal forebrain

  • pituitary gland

  • adrenal gland

  • hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neuropeptide binding
  • G protein-coupled receptor activity
  • signal transducer activity
  • somatostatin receptor activity
  • peptide binding
Cellular component
  • integral component of membrane
  • neuron projection
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • positive regulation of cytokinesis
  • G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • glucose homeostasis
  • signal transduction
  • negative regulation of cell population proliferation
  • regulation of insulin secretion
  • somatostatin signaling pathway
  • chemical synaptic transmission
  • cellular response to glucocorticoid stimulus
  • neuropeptide signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6755

20609

Ensembl

ENSG00000162009

ENSMUSG00000050824

UniProt

P35346

O08858

RefSeq (mRNA)

NM_001053
NM_001172560
NM_001172572
NM_001172573

NM_001191008
NM_011425

RefSeq (protein)

NP_001044
NP_001166031

NP_001177937
NP_035555

Location (UCSC)Chr 16: 1.07 – 1.08 MbChr 17: 25.71 – 25.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.[5]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162009 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050824 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics. 26 (3): 638–9. doi:10.1016/0888-7543(95)80195-R. PMID 7607700.
  6. ^ "Entrez Gene: SSTR5 somatostatin receptor 5".

Further reading

  • Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
  • Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. Bibcode:1984PNAS...81.3337M. doi:10.1073/pnas.81.11.3337. PMC 345502. PMID 6145156.
  • Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Mol. Pharmacol. 45 (3): 417–27. PMID 7908405.
  • O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Mol. Pharmacol. 46 (2): 291–8. PMID 8078491.
  • Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
  • Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
  • Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. doi:10.1210/jcem.82.6.4013. PMID 9177396. S2CID 25337792.
  • de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
  • Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi:10.1074/jbc.273.33.21416. PMID 9694905.
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/mend.13.1.0220. PMID 9892014.
  • Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.
  • Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101.
  • Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463): 154–7. Bibcode:2000Sci...288..154R. doi:10.1126/science.288.5463.154. PMID 10753124.
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. doi:10.1210/jcem.86.8.7787. PMID 11502816. S2CID 17616592.
  • Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
  • Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.

External links

  • "Somatostatin Receptors: sst5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
  • somatostatin+receptor+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • v
  • t
  • e
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
  • v
  • t
  • e
GH/IGF-1 axis signaling modulators
GH
(somatotropin)
  • Antisense oligonucleotides: Atesidorsen
  • Binding proteins: GHBPTooltip Growth hormone-binding protein
GHIH
(somatostatin)
  • Antagonists: BIM-23056
  • Cyclosomatostatin
  • CYN-154806
  • Satoreotide
GHRH
(somatocrinin)
  • Antagonists: MZ-5-156
GHS
(ghrelin)
  • Antagonists: A-778193
  • Cortistatin-8
  • (D-Lys³)-GHRP-6
  • JMV2959
  • YIL-781
IGF-1
(somatomedin)
  • See here instead.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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