FZD5

Uvojiti receptor 5

Identifikatori

FZD5; C2orf31; HFZ5

Vanjski ID

OMIM: 601723 MGI: 108571 HomoloGene: 2590 IUPHAR: FZD₅ GeneCards: FZD5 Gene

Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora • receptorsko vezivanje • proteinsko vezivanje • Wnt proteinsko vezivanje • vezivanje PDZ domena
Celularna komponenta	• citoplazma • ćelijska površina • integralno sa membranom • sinaptosom • membrana neuronske projekcije
Biološki proces	• pozitivna regulacija proteinske fosforilacije • razvoj vaskulature • morfogeneza odlivnog trakta • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

7855

14367

Ensembl

ENSG00000163251

ENSMUSG00000045005

UniProt

Q13467

Q9EQD0

RefSeq (mRNA)

NM_003468.3

NM_001033193.1

RefSeq (protein)

NP_003459.2

NP_001036124.1

Lokacija (UCSC)

Chr 2:
208.63 - 208.63 Mb

Chr 1:
64.78 - 64.78 Mb

PubMed pretraga

[1]

[2]

Uvojiti-5 je protein koji je kod ljudi kodiran FZD5 genom.^[1]^[2]^[3]

Reference

^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J Biol Chem. 271 (8): 4468—76. PMID 8626800. doi:10.1074/jbc.271.8.4468.
^ Saitoh T, Hirai M, Katoh M (2001). „Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region”. Int J Oncol. 19 (1): 105—10. PMID 11408929.
^ „Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)”.

Literatura

He X; Saint-Jeannet JP; Wang Y; et al. (1997). „A member of the Frizzled protein family mediating axis induction by Wnt-5A.”. Science. 275 (5306): 1652—4. PMID 9054360. doi:10.1126/science.275.5306.1652. CS1 одржавање: Експлицитна употреба et al. (веза)
Finch PW; He X; Kelley MJ; et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770. CS1 одржавање: Експлицитна употреба et al. (веза)
Tanaka S; Akiyoshi T; Mori M; et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164. CS1 одржавање: Експлицитна употреба et al. (веза)
Tamai K; Semenov M; Kato Y; et al. (2000). „LDL-receptor-related proteins in Wnt signal transduction.”. Nature. 407 (6803): 530—5. PMID 11029007. doi:10.1038/35035117. CS1 одржавање: Експлицитна употреба et al. (веза)
Wiemann S; Weil B; Wellenreuther R; et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”. Genome Res. 11 (3): 422—35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R. CS1 одржавање: Експлицитна употреба et al. (веза)
Yao R, Maeda T, Takada S, Noda T (2001). „Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.”. Biochem. Biophys. Res. Commun. 286 (4): 771—8. PMID 11520064. doi:10.1006/bbrc.2001.5430.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Weidler C; Schaumburger J; Miller LE; et al. (2004). „Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.”. J. Rheumatol. 31 (9): 1874—5. PMID 15338479. CS1 одржавање: Експлицитна употреба et al. (веза)
Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270. CS1 одржавање: Експлицитна употреба et al. (веза)
Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). „Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.”. Biochem. Biophys. Res. Commun. 328 (2): 533—9. PMID 15694380. doi:10.1016/j.bbrc.2005.01.009.
Hillier LW; Graves TA; Fulton RS; et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature. 434 (7034): 724—31. PMID 15815621. doi:10.1038/nature03466. CS1 одржавање: Експлицитна употреба et al. (веза)
Blumenthal A; Ehlers S; Lauber J; et al. (2006). „The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.”. Blood. 108 (3): 965—73. PMID 16601243. doi:10.1182/blood-2005-12-5046. CS1 одржавање: Експлицитна употреба et al. (веза)
Yamamoto H, Komekado H, Kikuchi A (2006). „Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.”. Dev. Cell. 11 (2): 213—23. PMID 16890161. doi:10.1016/j.devcel.2006.07.003.
Katoh Y, Katoh M (2007). „Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.”. Int. J. Oncol. 30 (3): 751—5. PMID 17273778.

Vidi još

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 25. 06. 2016. г.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)