DAPK3

Protein-coding gene in the species Homo sapiens
DAPK3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1YRP, 2J90, 3BHY, 3BQR, 5A6O, 5A6N

Identifiers
AliasesDAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDsOMIM: 603289; MGI: 1203520; HomoloGene: 20353; GeneCards: DAPK3; OMA:DAPK3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for DAPK3
Genomic location for DAPK3
Band19p13.3Start3,958,453 bp[1]
End3,971,123 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for DAPK3
Genomic location for DAPK3
Band10 C1|10 39.72 cMStart81,018,839 bp[2]
End81,029,031 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • gastric mucosa

  • popliteal artery

  • tibial arteries

  • ascending aorta

  • stromal cell of endometrium

  • right auricle

  • muscle layer of sigmoid colon

  • muscle of thigh

  • body of uterus
Top expressed in
  • yolk sac

  • muscle of thigh

  • lip

  • right kidney

  • superior frontal gyrus

  • primary visual cortex

  • granulocyte

  • spermatocyte

  • dentate gyrus of hippocampal formation granule cell

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein homodimerization activity
  • cAMP response element binding protein binding
  • kinase activity
  • protein serine/threonine kinase activity
  • leucine zipper domain binding
  • protein binding
  • identical protein binding
  • ATP binding
  • protein C-terminus binding
Cellular component
  • PML body
  • actin filament
  • membrane raft
  • nucleus
  • cytoplasm
Biological process
  • regulation of apoptotic process
  • regulation of actin cytoskeleton reorganization
  • negative regulation of translation
  • intracellular signal transduction
  • regulation of transcription, DNA-templated
  • regulation of smooth muscle contraction
  • phosphorylation
  • positive regulation of cell migration
  • positive regulation of canonical Wnt signaling pathway
  • regulation of myosin II filament organization
  • transcription, DNA-templated
  • regulation of cell motility
  • protein phosphorylation
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • regulation of autophagy
  • neuron differentiation
  • regulation of mitotic cell cycle
  • regulation of cell shape
  • positive regulation of apoptotic process
  • regulation of focal adhesion assembly
  • cellular response to interferon-gamma
  • apoptotic signaling pathway
  • protein autophosphorylation
  • regulation of translation
  • regulation of mitotic nuclear division
  • apoptotic process
  • peptidyl-serine phosphorylation
  • peptidyl-threonine phosphorylation
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1613

13144

Ensembl

ENSG00000167657

ENSMUSG00000034974

UniProt

O43293

O54784

RefSeq (mRNA)

NM_001348
NM_001375658

NM_001190473
NM_001190474
NM_007828

RefSeq (protein)

NP_001339
NP_001362587

NP_001177402
NP_001177403
NP_031854

Location (UCSC)Chr 19: 3.96 – 3.97 MbChr 10: 81.02 – 81.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[5][6]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[7]

Interactions

DAPK3 has been shown to interact with PAWR[8] and Death associated protein 6.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167657 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034974 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
  6. ^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3".
  7. ^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  8. ^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading

  • Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization". Journal of Human Genetics. 43 (3): 209–11. doi:10.1007/s100380050073. PMID 9747039.
  • Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H (May 1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters. 451 (1): 81–4. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987. S2CID 43329315.
  • Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters. 462 (1–2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. S2CID 6061613.
  • Page G, Kögel D, Rangnekar V, Scheidtmann KH (Dec 1999). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene. 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
  • Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF (Oct 2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Molecular and Cellular Biology. 22 (20): 6959–70. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
  • Preuss U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research. 31 (3): 878–85. doi:10.1093/nar/gkg176. PMC 149197. PMID 12560483.
  • Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
  • Burch LR, Scott M, Pohler E, Meek D, Hupp T (Mar 2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology. 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
  • Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME (Oct 2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase". The Journal of Biological Chemistry. 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
  • Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. S2CID 17142907.
  • Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L (Jun 2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3". International Journal of Andrology. 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
  • Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  • Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M (Dec 2006). "Novel ZIP kinase isoform lacks leucine zipper". Archives of Biochemistry and Biophysics. 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMC 2758612. PMID 17126281.
  • v
  • t
  • e
  • 1yrp: Catalytic domain of human ZIP kinase phosphorylated at Thr265
    1yrp: Catalytic domain of human ZIP kinase phosphorylated at Thr265
  • 2j90: CRYSTAL STRUCTURE OF HUMAN ZIP KINASE IN COMPLEX WITH A TETRACYCLIC PYRIDONE INHIBITOR (PYRIDONE 6)
    2j90: CRYSTAL STRUCTURE OF HUMAN ZIP KINASE IN COMPLEX WITH A TETRACYCLIC PYRIDONE INHIBITOR (PYRIDONE 6)
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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