Demecarium bromide
- S01EB04 (WHO)
- Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylammoniophenoxy)carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide
- 56-94-0 Y
- 5965
- DB00944 Y
- 5750 Y
- 61D5V4OKTP
- D00667 Y
- CHEBI:4391 Y
- ChEMBL1200514 N
- DTXSID6045240
- Interactive image
- [Br-].[Br-].O=C(Oc1cccc(c1)[N+](C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)[N+](C)(C)C)C)C
- InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 Y
- Key:YHKBUDZECQDYBR-UHFFFAOYSA-L Y
Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1]
Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.[3]
Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can be compounded.[5]
Use in dogs
When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[3]
See also
References
- ^ Jeske AH, ed. (2014). "Demecarium bromide". Mosby's dental drug reference (11th ed.). St. Louis, Missouri: Elsevier Mosby. p. 374. ISBN 978-0-323-16916-5.
- ^ Stein HA, Stein RM, Freeman M (2012). "Demecarium bromide (Humorsol)". Ophthalmic dictionary and vocabulary builder for eye care professionals (4th ed.). New Delhi: Jaypee Brothers Medical. p. 103. ISBN 9789350253656.
- ^ a b c d Maggs DJ, Miller PE, Ofri R (2013). "Indirect-acting parasympathomimetic agents". Slatter's Fundamentals of Veterinary Ophthalmology (5th ed.). St. Louis, Missouri: Elsevier. p. 51. ISBN 978-1-4377-2367-0.
- ^ Edmunds MW, Mayhew MS (2013). Pharmacology for the primary care provider (4th ed.). Elsevier Health Sciences. p. 174. ISBN 978-0-323-08790-2.
- ^ Alario AF, Strong TD, Pizzirani S (November 2015). "Medical Treatment of Primary Canine Glaucoma". The Veterinary Clinics of North America. Small Animal Practice. 45 (6): 1235–59, vi. doi:10.1016/j.cvsm.2015.06.004. PMID 26319445.
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- Apraclonidine
- Brimonidine (+timolol)
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- Dipivefrine
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muscarinic/nicotinic | |
acetylcholinesterase inhibitors |
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(sulfonamides)